Demographic and Clinical Characteristics of HC Subjects and PD Patients
| Parameter | n | Age (y) | Sex (F/M) | HY stage | Duration (y) | UPDRS motor |
|---|---|---|---|---|---|---|
| 18F-FPCIT | ||||||
| HC | 16 | 52.8 ± 17.1 | 11/5 | NA | NA | NA |
| PD | 25 | 60.0 ± 10.8 | 6/19 | 1.6 ± 1.0 | 4.8 ± 4.9 | 12.2 ± 9.6 |
| PD1 | 8 | 62.6 ± 7.1 | 0/8 | 1.2 ± 0.4 | 3.0 ± 3.1 | 8.4 ± 5.1 |
| PD2* | 66.4 ± 7.8 | 2.2 ± 0.4 | 6.8 ± 3.5 | 16.9 ± 5.0 | ||
| 18F-FDG | ||||||
| HC | 7 | 59.3 ± 13.5 | 3/4 | NA | NA | NA |
| PD | 18 | 60.4 ± 9.0 | 4/14 | 1.3 ± 0.4 | 2.8 ± 1.7 | 9.4 ± 4.9 |
| PD1 | 8 | 59.2 ± 8.0 | 1/7 | 1.2 ± 0.4 | 2.0 ± 1.3 | 9.6 ± 4.8 |
| PD2* | 63.0 ± 8.4 | 2.1 ± 0.4 | 5.8 ± 1.4 | 17.4 ± 4.9 |
*P < 0.0001, paired Student t tests of follow-up data compared with baseline.
HY= Hoehn and Yahr; UPDRS = unified PD rating scale; NA = not applicable.
PD1 and PD2 refer to baseline and 4-y scans of longitudinal PD group. Of 8 PD patients with follow-up, 7 had both 18F-FPCIT and 18F-FDG PET whereas the others underwent imaging with either tracer. Data are mean ± SD.