Demographic and Clinical Characteristics of Frontal Patient Groups
| Characteristic | bvFTD (n = 25) | bvNCD (n = 27) |
|---|---|---|
| Sex (% women) | 40 | 70* |
| Age (y) | ||
| Mean | 68.2 (11.3) | 75.8 (7.2)* |
| Range | 47–88 | 51–86 |
| Family history of dementia (%) | 32 | 22 |
| Vascular risk factors (%) | 44 | 81* |
| Symptom duration (y) | 5.3 (4.0) | 4.1 (2.9) |
| MMSE (0–30) | 24.7 (3.7) | 24.9 (3.5) |
| CDR of 0–3 | 1.86 (0.76) | 1.15 (0.55)* |
| CDR (n) | ||
| 0.5 | 1 | 6 |
| 1 | 7 | 14 |
| 2 | 12 | 7 |
| 3 | 5 | 0 |
| Impaired memory (%) | 84 | 100 |
| Impaired spatial abilities (%) | 4 | 15 |
| Impaired executive functions (%) | 80 | 78 |
| Decreased inhibition (%) | 52 | 15* |
| Apathy (%) | 80 | 44* |
| Loss of empathy (%) | 52 | 11* |
| Perseveration/compulsion (%) | 92 | 33* |
| Hyperorality (%) | 60 | 15* |
| Number of criteria over 6 | 4.2 (0.9) | 2 (0) |
| Anosognosia (%) | 64 | 41* |
| Frontal atrophy (GCAF 0–3) | 1.35 (0.69) | 1.38 (0.73) |
*Significant difference at P < 0.05.
MMSE = mini mental state exam; CDR = clinical dementia rating; GCAF = global cortical atrophy–frontal scale.
Values in parentheses are SD.