TABLE 3

Factors Associated with OS Among Patients with T3BN0M0 HCC

Characteristic	Univariate		Multivariate
Characteristic	HR	P	HR	P
Age (10-y change)	1.022 (0.990–1.056)	0.184	1.035 (0.998–1.072)	0.063
Sex, male (reference)	(reference)		(reference)
Sex, female	0.925 (0.852–1.003)	0.060	0.912 (0.840–0.990)	0.029
Race, white (reference)	(reference)		(reference)
Race, Hispanic	0.830 (0.741–0.930)	0.001	0.850 (0.754–0.959)	0.008
Race, black	0.947 (0.865–1.036)	0.232	0.933 (0.846–1.029)	0.164
Race, Asian + others	0.887 (0.791–0.994)	0.040	0.894 (0.793–1.008)	0.066
Uninsured (reference)	(reference)		(reference)
Private insurance	0.909 (0.787–1.051)	0.198	0.920 (0.793–1.067)	0.269
Medicaid/Medicare insurance	0.970 (0.843–1.116)	0.672	0.956 (0.827–1.106)	0.547
Other insurance	0.877 (0.659–1.167)	0.368	0.912 (0.685–1.215)	0.530
Median income, <$40,227 (reference)	(reference)		(reference)
Median income, $40,227–$50,353	1.024 (0.927–1.131)	0.638	0.978 (0.878–1.089)	0.682
Median income, $50,354–$63,332	0.923 (0.836–1.018)	0.107	0.884 (0.790–0.989)	0.032
Median income, $63,333+	0.991 (0.907–1.083)	0.841	0.949 (0.839–1.073)	0.404
Without high school degree, ≥17.6% (reference)	(reference)		(reference)
Without high school degree, 10.9%–17.5%	1.086 (0.993–1.189)	0.072	1.082 (0.981–1.193)	0.114
Without high school degree, 6.3%–10.8%	1.098 (1.005–1.199)	0.038	1.117 (1.003–1.244)	0.044
Without high school degree, <6.3%	1.088 (0.985–1.202)	0.097	1.131 (0.988–1.294)	0.073
Metro (reference)	(reference)		(reference)
Urban	1.134 (1.025–1.255)	0.014	1.106 (0.992–1.233)	0.070
Rural	1.276 (0.982–1.657)	0.068	1.171 (0.892–1.537)	0.255
Facility, academic (reference)	(reference)		(reference)
Facility, community cancer program	1.552 (1.311–1.838)	<0.001	1.376 (1.159–1.634)	<0.001
Facility, comprehensive community cancer program	1.247 (1.149–1.352)	<0.001	1.234 (1.135–1.342)	<0.001
Facility, integrated network	1.164 (1.055–1.285)	0.003	1.153 (1.043–1.275)	0.005
Region, Northeast (reference)	(reference)		(reference)
Region, Midwest	1.179 (1.069–1.301)	<0.001	1.167 (1.055–1.292)	0.003
Region, South	1.013 (0.929–1.105)	0.763	0.963 (0.879–1.054)	0.414
Region, West	1.000 (0.900–1.111)	0.996	0.987 (0.883–1.102)	0.813
Charlson index 0 or 1 (reference)	(reference)		(reference)
Charlson index 2	0.994 (0.878–1.126)	0.928	0.979 (0.863–1.109)	0.735
Charlson index 3	1.082 (0.989–1.184)	0.087	1.073 (0.979–1.177)	0.131
AFP, normal (reference)	(reference)		(reference)
AFP, elevated	1.330 (1.202–1.473)	<0.001	1.356 (1.220–1.506)	<0.001
MELD score (10-unit change)	1.134 (1.084–1.186)	<0.001	1.113 (1.061–1.167)	<0.001
Treatment, systemic (reference)	(reference)		(reference)
Treatment, TARE	0.745 (0.691–0.803)	<0.001	0.739 (0.684–0.798)	<0.001

Data in parentheses are 95% CIs.