Variables Collected in Submission Process, with Research Questions Expected to Be Answered with Those Variables
| Category | Variables collected | Research questions asked |
|---|---|---|
| Expertise | Submitter title | Is procedure being performed by technologist, physicist, physician, or other? |
| Software and dosimetry type | Software used; type of dosimetry calculations performed; Monte Carlo code used (if applicable); S-factor source | Is voxelized or tissue-level dosimetry being performed? Is commercial software being used, or is in-house software being used? How are voxelized calculations performed, and what code is used for voxelized S-factor kernels? |
| VOI delineation | Image or images used for delineation; delineation method; threshold value (if fixed-threshold methods used); method for mass and activity determination; time needed; screenshots of generated VOIs | Are VOIs drawn using diagnostic pretherapy images, or only on SPECT, or only on therapeutic CT? Are manual, fixed thresholding, or AI methods used for segmentation? How were masses and activities of organ/tumor estimated? How much time does segmentation process take? |
| TIA generation | Method of integration; fit function; number of fit parameters; time needed; screenshots of time–activity curves | Are fits being performed using exponential, biexponential, or other types of functions? What is variability in TIA? How much time is required to perform this step of procedure? |
| Dose results | Volume of organ/tumor; mass of organ/tumor; total measured activity at each scan time-point; values of fit parameters; units of fit parameters; mean dose rates of each organ at each scan time-point; dose results; radiobiology results if applicable | What is variability in fit parameters? What is variability in mass and activity values measured in organs/tumors? What is variability in dose values and dose rates (if applicable)? How common is it to see radiobiology metrics reported? How do they vary? |