Clinical value of myocardial blood flow reserve
| No known CAD |
| High negative predictive value in combination with normal perfusion |
| Confirm an abnormality is CAD |
| Predict more severe disease: e.g., 1-vessel abnormal perfusion, 2-3-vessel abnormal MBFR |
| Confirm single vessel disease: 1 vessel abnormal perfusion, 1 vessel abnormal MBFR Normal perfusion, abnormal MBFR: identify balanced CAD, microvascular disease |
| Identify non-responder: all patients |
| Known CAD |
| Often abnormal after CABG, CAD history, myocardial infarction |
| Cardiomyopathy less useful but if normal, helps exclude CAD |
| Renal failure patients generally abnormal |
| Post PCI may be abnormal, but most useful if pre-PCI data available |
| Identify non-responder: all patients |