TABLE 2

Staging Results and Impact on Patient Management

	Rated positive for MZL		BM/GI involvement		Ann Arbor classification		Changes due to CXCR4 PET/CT
Patient no.	Conv.	CXCR4	Conv.	CXCR4	Conv.	CXCR4	Staging	Treatment protocol
1	Yes^*	No			I	—	Down	Deescalation to watch and wait (RTx)
2	Yes	Yes		BM	IV	IV
3	Yes	Yes			IV	IV
4	Yes	Yes	GI		I	IV	Up
5	No	Yes			—	I	Up	Escalation to RTx (none)
6	No	No			—	—
7	Yes	Yes			IV	IV		Escalation to CTx (RTx); at f/u: CXCR4⁺ lesion → RTx
8	Yes	Yes			I	IV	Up	Escalation to RTx of 3 lesions (RTx 1 lesion)
9	No	Yes			—	II	Up	Escalation to RTx (none)
10	Yes	Yes			III	III
11	Yes	Yes	GI	GI, BM^*	I	IV	Up	Escalation of RTx (smaller radiation field)
12	Yes	Yes	GI	GI	I	I
13	Yes	Yes			III	II	Down
14	Yes	Yes			IV	II	Down
15	Yes	Yes	BM^*	BM^*	IV	IV
16	Yes	Yes	BM	BM	IV	IV
17	Yes	Yes	BM	BM	IV	IV
18	Yes	Yes			I	I
19	Yes	Yes	GI	GI	IV	IV		Deescalation to watch and wait (RTx)
20	No	Yes			—	II	Up	escalation to RTx (none)
21	Yes	Yes			III	III
22	No	Yes	GI^*		—	II	Up

↵* False-positive.
GI = gastrointestinal; Conv. = conventional staging; RTx = radiation; CTx = chemotherapy; f/u = follow-up.
Parentheses in last column indicate initially planned therapy.