Detection Rates of Suspected Lesions and Equivocal Lesions and Testing of Equality for Detection of Suspected Lesions Between 18F-DCFPyL and 18F-PSMA-1007 for Total Cohort
| Reader 1 | Reader 2 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 18F-DCFPyL | 18F-PSMA-1007 | P | 18F-DCFPyL | 18F-PSMA-1007 | P | ||||||
| General site | Specific site | Suspected malignant | Equivocal | Suspected malignant | Equivocal | Suspected malignant | Equivocal | Suspected malignant | Equivocal | ||
| Prostate | 86 (72) | 4 (3) | 98 (82) | 7 (6) | 0.045* | 86 (72) | 5 (4) | 102 (85) | 1 (1) | 0.015* | |
| Lymph nodes | Inguinal | 4 (3) | 0 (0) | 2 (2) | 0 (0) | 0.409 | 4 (3) | 0 (0) | 1 (1) | 2 (2) | 0.984 |
| Pelvis | 52 (43) | 2 (2) | 55 (46) | 4 (3) | 0.409 | 52 (43) | 2 (2) | 55 (46) | 5 (4) | 0.460 | |
| Abdomen | 36 (30) | 0 (0) | 31 (26) | 0 (0) | 0.473 | 41 (34) | 2 (2) | 34 (28) | 2 (2) | 0.331 | |
| Mediastinum | 12 (10) | 0 (0) | 7 (6) | 4 (3) | 0.760 | 13 (11) | 4 (3) | 10 (8) | 1 (1) | 0.332 | |
| Axillae | 6 (5) | 0 (0) | 1 (1) | 0 (0) | 0.056 | 6 (5) | 0 (0) | 1 (1) | 0 (0) | 0.056 | |
| Neck | 12 (10) | 0 (0) | 11 (9) | 1 (1) | 0.983 | 18 (15) | 0 (0) | 11 (9) | 1 (1) | 0.231 | |
| Whole body | 52 (43) | 2 (2) | 56 (47) | 5 (4) | 0.463 | 55 (46) | 4 (3) | 58 (48) | 6 (5) | 0.691 | |
| Bone | Pelvis | 32 (27) | 2 (2) | 44 (37) | 5 (4) | 0.053 | 32 (27) | 0 (0) | 40 (33) | 13 (11) | 0.027* |
| Spine | 28 (23) | 2 (2) | 34 (28) | 4 (3) | 0.215 | 26 (22) | 1 (1) | 34 (28) | 10 (8) | 0.060 | |
| Thorax | 23 (19) | 4 (3) | 29 (24) | 17 (14) | 0.015* | 24 (20) | 5 (4) | 28 (23) | 40 (33) | <0.001* | |
| Extremities | 22 (18) | 0 (0) | 18 (15) | 4 (3) | 0.929 | 22 (18) | 0 (0) | 18 (15) | 4 (3) | 0.929 | |
| Whole skeleton | 40 (33) | 4 (3) | 50 (42) | 17 (14) | 0.009* | 36 (30) | 5 (4) | 44 (37) | 40 (33) | <0.001* | |
| Other | Lung | 1 (1) | 4 (3) | 1 (1) | 7 (6) | 0.389 | 1 (1) | 6 (5) | 2 (2) | 6 (5) | 0.800 |
| Liver | 1 (1) | 0 (0) | 2 (2) | 1 (1) | 0.312 | 0 (0) | 1 (1) | 2 (2) | 1 (1) | 0.318 | |
| Funiculus | 0 (0) | 2 (2) | 0 (0) | 0 (1) | 0.156 | 2 (2) | 0 (0) | 0 (0) | 0 (0) | 0.800 | |
| Adrenals | 1 (1) | 0 (0) | 1 (1) | 1 (1) | 0.559 | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 1.000 | |
| Pleural | 0 (0) | 0 (0) | 0 (0) | 1 (1) | 0.317 | 0 (0) | 0 (0) | 0 (0) | 1 (1) | 0.317 | |
| Thyroid | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 1.000 | 0 (0) | 0 (0) | 0 (0) | 1 (1) | 0.317 | |
| All other | 3 (3) | 6 (5) | 4 (3) | 10 (8) | 0.270 | 3 (3) | 7 (6) | 4 (3) | 9 (8) | 0.513 |
↵* Statistically significant (P < 0.05; Mann–Whitney U test).
Data are number followed by percentage in parentheses. Suspected malignant PSMA is RADS 4 and 5; equivocal PSMA is RADS 3a, 3b, 3c, and 3d.