Key Findings from Literature Regarding Presence or Absence of Flare Phenomenon on PSMA-Targeted PET on Initiation of Androgen-Axis Targeted Therapeutic Agents
| Study | Patients (n) | Therapy initiated | Key results |
|---|---|---|---|
| Hope (7) | 1 | ADT | Flare on 4-wk follow-up scan |
| Afshar-Oromieh (8) | 10 | ADT | Long-term ADT, decreased conspicuity of lesions |
| Aggarwal (10) | 8 | ADT in 4 patients, enzalutamide in 4 patients | Variably observed heterogeneous flare |
| Emmett (19) | 15 | ADT in 8 patients, enzalutamide or abiraterone in 7 patients | Mix of flare and true progression |
| Plouznikoff (11) | 26 | Enzalutamide or abiraterone | No evidence of flare |
ADT = androgen deprivation therapy.