TABLE 3

18F-MNI-968 VT and BPND in Pooled Rhesus and Cynomolgus Macaques

VTBPND
Region2TLGA2TLGASRTMNI-LGA
Striatum4.1 ± 0.2 (4%)4.0 ± 0.2 (4%)1.14 ± 0.05 (5%)1.07 ± 0.02 (2%)1.07 ± 0.03 (2%)1.08 ± 0.03 (3%)
Caudate4.0 ± 0.3 (8%)3.9 ± 0.3 (8%)1.08 ± 0.12 (11%)1.02 ± 0.09 (9%)1.06 ± 0.09 (8%)1.06 ± 0.08 (8%)
Putamen4.3 ± 0.2 (4%)4.1 ± 0.2 (4%)1.20 ± 0.09 (8%)1.13 ± 0.10 (9%)1.11 ± 0.08 (7%)1.12 ± 0.08 (8%)
Nucleus accumbens3.2 ± 0.2 (5%)3.1 ± 0.2 (6%)0.65 ± 0.02 (4%)0.61 ± 0.00 (0%)0.59 ± 0.07 (12%)0.60 ± 0.07 (12%)
Globus pallidus3.2 ± 0.6 (18%)3.1 ± 0.5 (18%)0.65 ± 0.20 (31%)0.60 ± 0.21 (35%)0.58 ± 0.18 (31%)0.58 ± 0.18 (31%)
Thalamus2.6 ± 0.2 (9%)2.6 ± 0.2 (9%)0.35 ± 0.04 (13%)0.33 ± 0.04 (13%)0.29 ± 0.05 (19%)0.29 ± 0.06 (20%)
Frontal cortex2.6 ± 0.1 (2%)2.4 ± 0.1 (2%)0.33 ± 0.08 (25%)0.27 ± 0.04 (15%)0.28 ± 0.05 (17%)0.28 ± 0.05 (18%)
Cerebellum1.9 ± 0.1 (6%)1.9 ± 0.1 (5%)
  • Data are mean ± SD, followed by coefficient of variation in parentheses (n = 3 for 2T and LGA, and n = 5 for SRTM and NI-LGA).