TABLE 2

Demographics of Study Cohort (n = 38)

Characteristic	Parameter	n	%
Total		38	100
Sex	Male	15	39
	Female	23	61
Age (y)	Median	66
	Range	28–81
Primary site	Lung	38	100
Grade for bronchial NEN	Typical carcinoid	9	24
	Atypical carcinoid	22	58
	LCNEC	3	8
	SCNEC	1	3
	Unknown^*	3	8
Mitotic count	Median	3.5
	Range	0–50
Ki-67 index	Median	15
	Range	1–80
Necrosis	Yes	16	42
	No	11	29
	Unknown	11	39
Site of metastasis	Lungs	19	50
	Lymph nodes	19	50
	Liver	21	55
	Bone	23	61
	Brain	4	11
	Other^{^†}	11	32
Extrahepatic disease	Yes	36	95
	No	2	5
Received PRRT	Yes	19	50
	No	19	50

↵* Of these 3 cases, 2 were well-differentiated NEN without specific comment on histologic report as to whether this represented typical or atypical carcinoid. One was mixed high-grade and low-grade NEN.
↵^† Other sites of disease included peritoneum (4 patients), pancreas (3 patients), adrenal glands (2 patients), pericardium (1 patient), and ovary (1 patient).
LCNEC = large cell neuroendocrine carcinoma; SCNEC = small cell neuroendocrine carcinoma.