TABLE 1

Scheme of Cohorts

CohortPatients (n)TF2 dose (nmol)Delay (h)68Ga-IMP288 dose and activity (nmol)MBqTF2/IMP288 molar dose ratio
I312024615020
II3 + 9*12030615020
III3 + 112042615020
IV312030315040
V36030315020
  • * Three patients in optimization phase of study and 9 in validation phase.

  • Patient 8 did not receive full hapten dose and was excluded and replaced for optimization phase study but was reintegrated for sensitivity study.