TABLE 1

Drugs Inhibiting In Vitro Transporters Involved in Hepatic Disposition of 99mTc-Mebrofenin (35–38)

TransporterInhibitor
OATP1B1Atazanavir, atorvastatin, budesonide, carfilzomib, cyclosporin, clarithromycin, diclofenac, dipyridamole, dronedarone, elacridar, erythromycin, flavonoids, fluvastatin, fosinopril, gemfibrozil, glibenclamide, gliquidone, lapatinib, lopinavir, pitavastatin, rapamycin, repaglinide, rifampicin, ritonavir, rosuvastatin, roxithromycin, sirolimus, sulfasalazine, telithromycin, telmisartan, trametinib, valspodar
OATP1B3Atazanavir, atorvastatin, budesonide, carfilzomib, clarithromycin, cyclosporin, clarithromycin, dipyridamole, dronedarone, flavonoids, fluvastatin, fosinopril, gemfibrozil, glibenclamide, gliquidone, lapatinib, lopinavir, pitavastatin, rapamycin, repaglinide, rifampicin, ritonavir, rosuvastatin, sildenafil, sirolimus, sulfasalazine, telmisartan, trametinib, valspodar
MRP2Benzbromarone, cyclosporin, diltiazem, dipyridamole, ivermectin, lansoprazole, loperamide, lopinavir, reserpine, rifampicin, ritonavir, saquinavir, silymarin, tamoxifen, terfenadine
MRP3Alpidem, benzbromarone, chloramphenicol, chlorpromazine, clozapine, cyclosporin, desipramine, dicloxacillin, etoposide, finasteride, fluoxetine, fluvastatin, furosemide, glibenclamide, haloperidol, indinavir, indomethacin, lopinavir, maprotiline, mibefradil, nadolol, nifedipine, nortriptyline, oxybutynin, primaquine, probenecid, promethazine, quinidine, rifamycin SV, ritonavir, simvastatin, sorafenib, sulfasalazine, tamoxifen, taxol, tolbutamide, tolcapone, troglitazone, valinomycin, verapamil, vinblastine