TABLE 2
Comparison of Reduced-Time-Point (TP) Methods for Virtual Cohort (500 Kidneys)
| Metric | Mono 1 TP Madsen | Bi 1 TP Madsen | 1 TP Hanscheid | 1 TP MM | 2 TP MM | 2 TP Mono |
|---|---|---|---|---|---|---|
| Mean % bias | 0.7 [−35.1, 17.5] | −3.0 [-38.2, 11.9] | 2.7 [−36.1, 18.5] | −1.9 [−19.2, 10.7] | −1.2 [−23.0, 10.1] | 6.3 [−12.8, 1061.9] |
| # kidneys with |bias| > 10% | 85 (17.0%) | 73 (14.6%) | 102 (20.4%) | 32 (6.4%) | 15 (3.0%) | 70 (14.0%) |
| # kidneys with |bias| > 15% | 26 (5.2%) | 36 (7.2%) | 37 (7.4%) | 5 (1.0%) | 2 (0.4%) | 41 (8.2%) |
| # kidneys with |bias| > 20% | 10 (2.0%) | 18 (3.6%) | 10 (2.0%) | 0 (0.0%) | 1 (0.2%) | 31 (6.2%) |
| # kidneys with |bias| > 25% | 6 (1.2%) | 8 (1.6%) | 8 (1.6%) | 0 (0.0%) | 0 (0.0%) | 21 (4.2%) |
| RMSE | 0.09 | 0.09 | 0.09 | 0.06 | 0.05 | 0.43 |
| Mean R2 of curve fit | 0.87 [0.59, 0.93] | 0.98 [0.82, 0.99] | —* | 0.98 [0.82, 0.99] | 0.99 [0.93, 0.99] | 0.89 [0.74, 0.93] |
* Hanscheid approximation provides TIA and not a curve fit.
and 
MM = mixed model. Mono and Bi refer to monoexponential and biexponential, respectively. Data in square brackets are minimum and maximum, respectively.