1 | 99mTc-mebrofenin represents translational molecular imaging probe to explore canalicular MRP2, as well as sinusoidal OATP and MRP3 function in hepatocytes |
2 | In patients, kinetic modeling may enable interpreting dynamic 99mTc-mebrofenin scintigraphy data from molecular perspective |
3 | Because of its widespread availability, 99mTc-mebrofenin can potentially be used as phenotyping probe to safely and selectively investigate risk for transporter-mediated DDIs in drug development and to explore pathophysiologic regulations of hepatocyte transporter function |
4 | Preclinical data suggest that liver uptake phase of 99mTc-mebrofenin can be prolonged by targeted inhibition of MRP2, thereby potentially providing improved assessment of functional liver volume with SPECT |