Results of Cox Proportional Hazards Regression Analyses of OS Probability After Initiation of Abiraterone or Enzalutamide Therapy
| Univariate | Multivariate | |||
|---|---|---|---|---|
| Parameter | HR | P | HR | P |
| mCRPC patients (n = 71) | ||||
| Age at start of treatment | 1.03 [0.99, 1.06] | 0.11 | ||
| Treatment agent | 0.48 | |||
| Enzalutamide (n = 32) | Reference | |||
| Abiraterone (n = 39) | 1.21 [0.71, 2.08] | |||
| Laboratory parameters at treatment start | ||||
| Prostate-specific antigen (log) | 1.13 [0.95, 1.35] | 0.17 | ||
| Albumin | 0.55 [0.23, 1.31] | 0.18 | ||
| Alkaline phosphatase (log) | 1.90 [1.34, 2.70] | <0.001 | Not selected | |
| Hemoglobin | 0.80 [0.67, 0.95] | 0.013 | 0.81 [0.69, 0.96] | 0.013 |
| Lactate dehydrogenase | 1.005 [1.003, 1.008] | <0.001 | Not selected | |
| 18F-FDG PET/CT metrics | ||||
| SUVmax (g/mL) | 1.14 [1.08, 1.21] | <0.001 | Not selected | |
| Number of 18F-FDG–avid metastases | 1.08 [1.05, 1.11] | <0.001 | Not selected | |
| Whole-body MTV (log) | 1.86 [1.49, 2.33] | <0.001 | Not selected | |
| Whole-body TLG (log) | 1.84 [1.51, 2.26] | <0.001 | 1.88 [1.53, 2.32] | <0.001 |
| mCSPC patients (n = 25) | ||||
| Age at start of treatment | 1.02 [0.9, 1.15] | 0.76 | ||
| Treatment agent | 0.72 | |||
| Enzalutamide (n = 7) | Reference | |||
| Abiraterone (n = 18) | 0.73 [0.13, 3.98] | |||
| Laboratory parameters at treatment start | ||||
| Prostate-specific antigen (log) | 1.07 [0.72, 1.58] | 0.74 | ||
| Albumin | 1.29 [0.9, 17.2] | 0.85 | ||
| Alkaline phosphatase (log) | 1.55 [0.59, 4.05] | 0.37 | ||
| Hemoglobin | 0.66 [0.43, 1.03] | 0.065 | ||
| Lactate dehydrogenase | 1.00 [0.98, 1.02] | 0.89 | ||
| 18F-FDG PET/CT metrics | ||||
| SUVmax (g/mL) | 0.99 [0.90, 1.09] | 0.80 | ||
| Number of 18F-FDG–avid metastases | 1.03 [0.96, 1.11] | 0.43 | ||
| Whole-body MTV (log) | 1.21 [0.83, 1.76] | 0.33 | ||
| Whole-body TLG (log) | 1.18 [0.86, 1.61] | 0.31 | ||
“Treatment” indicates treatment with abiraterone plus prednisone, or enzalutamide. “Not selected” indicates not selected during stepwise selection. Data in brackets are 95% CIs.