GLP-1R Expression in Different Diseases and Normal Organs
| Characteristics of GLP-1R expression | Tissue sample | GLP-1R density* | GLP-1R incidence | Reference |
|---|---|---|---|---|
| Disease with high GLP-1R density and incidence | Benign insulinoma | 8133 | 25/27, 93% | (15,19) |
| Diseases with high GLP-1R density but moderate incidence | Malignant insulinoma | 8508 | 4/11, 36% | (18) |
| Diseases with moderate GLP-1R density but high incidence | Gastrinoma | 2461 | 10/10, 100% | (15) |
| Adult nesidioblastosis after gastric bypass surgery | 1483 | 7/7, 100% | (17) | |
| Diseases with moderate GLP-1R density and incidence | Pheochromocytoma | 3970 | 12/20, 60% | (16) |
| NETs of the lung | 2456 | 11/29, 38% | (15) | |
| Paraganglioma | 1353 | 5/18, 28% | (16) | |
| Medullary thyroid carcinoma | 1326 | 5/18, 28% | (16) | |
| Disease with expected GLP-1R expression | Congenital hyperinsulinism | ND | ND | |
| Organs with GLP-1R expression | Neurohypophysis | 5207 | 6/6, 100% | (16) |
| Duodenum Brunner’s glands | 2752 | 5/5, 100% | (16) | |
| Pancreas islets | 1322 | 24/24, 100% | (16) | |
| Pancreas acini | 693 | 9/9, 100% | ||
| Kidney, large- and medium-sized arteries | 674 | 2/2, 100% | (16) |
↵* GLP-1R density is given as mean in degradation per minutes per mg tissue (dpm/mg tissue). ND = not done.