TABLE 5

Pharmacokinetic Parameters of ABT-806i and ABT-806

Cohort (ABT-806 dose group)	ABT-806i (mg)	ABT-806 (mg/kg)	n	T_max (hr)	C_max (μg/mL)	C_max/dose (μg/mL)/(mg/kg)	T_1/2 (d)^*	AUC (mg*h/mL)^†	AUC/dose (mg*h/mL)/(mg/kg)^†	CL (mL/h)
ABT-806i (week 1, day 1)
1	3–5	N/A	6	0.41 ± 0.46	1.61 ± 0.50	23.4 ± 5.2	6.0 ± 1.5	0.274 ± 0.080	4.07 ± 1.10	19.4 ± 6.6
2 (18 mg/kg)	3–5	N/A	6	0.11 ± 0.04	1.62 ± 0.32	22.2 ± 4.7	5.6 ± 1.5	0.243 ± 0.062	3.36 ± 1.03	21.3 ± 6.1
2 (24 mg/kg)	3–5	N/A	6	0.15 ± 0.10	1.75 ± 0.39	22.7 ± 5.4	5.3 ± 2.4	0.261 ± 0.113	3.49 ± 1.90	24.5 ± 15.9
2 (18 and 24 mg/kg)	3–5	N/A	12	0.13 ± 0.08	1.69 ± 0.35	22.4 ± 4.8	5.4 ± 1.9	0.252 ± 0.088	3.42 ± 1.46	22.9 ± 11.6
ABT-806 + ABT-806i (week 6, day 1)
2 (18 mg/kg)	3–5	N/A	6	2.25 ± 0.49	531 ± 136	29.5 ± 7.6	14.5 ± 4.3	99.8 ± 27.9	5.54 + 1.55	13.3 ± 4.6
2 (24 mg/kg)	3–5	N/A	6	2.16 ± 0.61	742 ± 128	30.9 ± 5.3	8.6 ± 2.3	116.2 ± 38.6	4.84 ± 1.61	14.8 ± 5.1

↵* Harmonic mean and pseudostandard deviation.
↵† AUC_∞ for week 1, day 1 and AUC_TAU for week 6, day 1.
T_max = time to maximum concentration in serum; C_max = maximum observed plasma concentration; t_1/2 = terminal elimination half-life; AUC = area under the curve; CL = clearance; N/A = not applicable.