TABLE 2

Diagnostic Utility in Detecting None-to-Low vs. Intermediate-to-High ADNC

Parameter n AUC ± SECutoffSensitivitySpecificity
PCA-based
 18F-FDG380.72 ± 0.09* 8.320.73 [0.52–0.88]0.67 [0.35–0.90]
 18F-FDG220.80 ± 0.10* 7.390.79 [0.49–0.95]0.75 [0.35–0.97]
 Aβ220.95 ± 0.05 −17.631.00 [0.77–1.00]0.75 [0.35–0.97]
 Combined220.98 ± 0.02 −0.771.00 [0.77–1.00]0.88 [0.47–1.00]
VOI-based
 18F-FDG380.66 ± 0.111.090.73 [0.52–0.88]0.67 [0.35–0.90]
 18F-FDG220.79 ± 0.12* 1.090.85 [0.57–0.98]0.75 [0.35–0.97]
 Aβ220.88 ± 0.10 1.231.00 [0.77–1.00]0.75 [0.35–0.97]
 Combined220.90 ± 0.08 −0.521.00 [0.77–1.00]0.75 [0.35–0.97]
  • * P < 0.05 (significance level vs. chance [AUC = 0.50]).

  • P < 0.001 (significance level vs. chance [AUC = 0.50]).

  • n = number of patients in dataset.

  • Data in brackets are 95% CIs.