Demographic Characteristics of ADNI Subcohort with Available Neuropathology Data According to Antemortem Clinical Diagnostic Groups
| Characteristic | AD | MCI | Cognitively normal |
| Subjects with 18F-FDG PET available | |||
| Number of subjects | 30 | 6 | 2 |
| Age at scan (y) | 79.2 ± 8.0 | 82.7 ± 6.0 | 76.1 ± 13.6 |
| Age at autopsy (y) | 82.1 ± 8.1 | 85.0 ± 5.0 | 79.5 ± 13.4 |
| Scan-deaths (y) | 2.9 ± 1.7 | 2.1 ± 1.4 | 3.5 ± 0.7 |
| Mini-mental state examination | 21.7 ± 4.3 | 26.7 ± 2.4 | 30 ± 0 |
| Education (y) | 16.5 ± 2.3 | 14.6 ± 2.1 | 19.0 ± 1.4 |
| PES of 18F-FDG-ADCRP* | 12.4 ± 8.8 | 6.0 ± 5.3 | −5.7 ± 5.5 |
| 18F-FDG uptake* | 1.04 ± 0.09 | 1.10 ± 0.08 | 1.21 ± 0.03 |
| Neuropathologic diagnosis: Braak tangles stage | ADNC (24): 2–6 | ADNC (5): 1–5 | ADNC (1): 0 |
| DLB (4): 2–4 | AD (1): 5 | PART (1): 2 | |
| FTLD-TDP (1): 1 | |||
| HS (1): 2 | |||
| Subjects with Aβ PET available | |||
| Number of subjects with Aβ PET available | 17 | 3 | 2 |
| Age at scan (y) | 80.2 ± 8.6 | 83.9 ± 5.3 | 76.6 ± 15.2 |
| Age at autopsy (y) | 82.6 ± 8.4 | 85.6 ± 5.5 | 79.5 ± 13.4 |
| Scan-deaths (y) | 2.4 ± 1.1 | 1.7 ± 0.7 | 2.9 ± 1.8 |
| MMSE* | 23.4 ± 3.1 | 27.3 ± 2.0 | 30 ± 0 |
| Education (y) | 17.2 ± 1.75 | 14.6 ± 3.0 | 19.0 ± 1.4 |
| Aβ PET SUVr | 1.43 ± 0.28 | 1.40 ± 0.20 | 1.43 ± 0.27 |
| PES of Aβ-ADCRP | 10.4 ± 24.6 | 3.5 ± 18.9 | −9.9 ± 27.1 |
| Neuropathologic diagnosis: Thal amyloid phase | ADNC (13): 4–5 | ADNC (2): 4 | ADNC (1): 1 |
| DLB (2): 1 | AD (1): 5 | PART (1): 0 | |
| FTLD-TDP (1): 1 | |||
| HS (1): 1 |
↵* Significantly different between groups (ANOVA, P < 0.01).
DLB = dementia with Lewy bodies; PART = primary age-related tauopathy; FTLD-TDP = frontotemporal lobar degeneration with TDP-43 inclusions; HS = hippocampal sclerosis.
Qualitative data are numbers; continuous data are mean ± SD. All subjects were male.