TABLE 1

Efficacy, Toxicity, and Whole-Body Absorbed Dose for ¹⁷⁷Lu Radioimmunotherapy in MM1-S Disseminated MM

			¹⁷⁷Lu-DOTA-daratumumab
Parameter	Vehicle control (n ≤ 10)^*	Daratumumab (n ≤ 4)	1.85 MBq (n ≤ 4)	3.7 MBq (n ≤ 5)	7.4 MBq (n ≤ 5)	11.1 MBq (n ≤ 4)
Duration of tumor growth delay (days after MM1-S injection)	0	0	0	33	33	32
Start of weight loss (days after MM1-S injection)	28^†	26^†	33^†	33^‡	33^‡	26^‡
Median survival (days after MM1-S injection)	33	31	44	54	47	36
Whole-body absorbed dose (Gy)	—	—	0.9	1.9	4.1	6.4

↵* Combined vehicle control groups from all ¹⁷⁷Lu experiments.
↵† Weight loss due to MM burden.
↵‡ Weight loss due to radioimmunotherapy toxicity.
Mean value of all mice in each condition is given except for survival, which is median.