Diagnostic Value of 18F-FLT PET/CT After Positive 18F-FDG PET/CT
| Group | Pretest probability of malignancy* | Sensitivity | Specificity | Positive likelihood ratio | Negative likelihood ratio | Positive predictive value | Negative predictive value | Accuracy |
|---|---|---|---|---|---|---|---|---|
| Patients | ||||||||
| All (n = 44) | 70% | 74% (55%–88%) | 77% (46%–95%) | 3.2 (1.2–8.9) | 0.3 (0.2–0.7) | 88% (74%–95%) | 56% (39%–71%) | 75% (60%–87%) |
| cRT (n = 25) | 72% | 72% (47%–90%) | 100% (59%–100%) | NA | 0.3 (0.1–0.6) | 100% | 58% (40%–75%) | 80% (59%–93%) |
| SBRT (n = 20) | 70% | 79% (49%–95%) | 50% (12%–88%) | 1.6 (0.7–3.7) | 0.4 (0.1–1.5) | 79% (61%–90%) | 50% (22%–78%) | 70% (46%–88%) |
| HDVs | ||||||||
| All (n = 30) | 50% | 73% (45%–92%) | 87% (60%–98%) | 5.5 (1.5–20.7) | 0.3 (0.1–0.7) | 85% (59%–95%) | 76% (58%–89%) | 80% (61%–92%) |
| cRT (n = 21) | 67% | 71% (42%–92%) | 100% (59%–100%) | NA | 0.3 (0.1–0.7) | 100% | 64% (43%–80%) | 81% (58%–95%) |
| SBRT (n = 9) | 11% | 100% (3%–100%) | 75% (35%–97%) | 4.0 (1.2–13.3) | 0 | 33% (13%–62%) | 100% | 78% (40%–97%) |
↵* Positive predictive value for positive or inconclusive 18F-FDG PET/CT results.
NA = not applicable.
Data in parentheses are 95% CIs.