TABLE 3

FDA-Approved Antiresorptive and Anabolic Therapies Used in Randomized Clinical Trials (53,54)

DrugName of studyNo. of patientsRR% of vertebral FxRR% of hip Fx
Antiresorptive therapies
 CalcitoninPROOF1,25536NS
 RaloxifeneMORE7,70430–55NS
 HRT/ERTWHI16,6083434–39
 AlendronateFIT-12,0274751
 RisedronateVERT2,45841–49NA
 RisedronateHIP-OP5,445NA40
 IbandronateBONE2,94652NS
 Zoledronic acidHORIZON7,7657041
 DenosumabFREEDOM7,8686840
Anabolic therapies
 TeriparatideNCT00670501*1,63784NA
 AbaloparatideACTIVE2,4638643 (NV Fx)
 RomosozumabFRAME7,18083NS
  • * ClinicalTrials.gov identifier.

  • RR = relative risk reduction; Fx = fracture; HRT/ERT = hormone replacement therapy/estrogen replacement therapy; NS = not significant; NA = not available; NV Fx = nonvertebral fracture.