RT Journal Article
SR Electronic
T1 Dual Positron Emission Tomography imaging in bronchial neuroendocrine neoplasms (NENs): The NETPET score as a prognostic biomarker
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP jnumed.120.257659
DO 10.2967/jnumed.120.257659
A1 David L Chan
A1 Gary A Ulaner
A1 David A. Pattison
A1 David Wyld
A1 Rahul Ladwa
A1 Julian Kirchner
A1 Bob T Li
A1 W. Victoria Lai
A1 Nick Pavlakis
A1 PAUL J ROACH
A1 Dale L. Bailey
YR 2021
UL http://jnm.snmjournals.org/content/early/2021/02/12/jnumed.120.257659.abstract
AB Background: PET scans using [18F]FDG and somatostatin receptor imaging agents are both used in imaging of neuroendocrine neoplasms (NENs). We have suggested the “NETPET score”, utilizing uptake of both PET tracers, as a prognostic biomarker in NENs. We previously demonstrated the effectiveness of the NETPET score in gastroenteropancreatic (GEP) NENs. Its prognostic relevance in bronchial NENs remains undetermined. Methods: This is a retrospective multicentre study (2011-2018) assessing patients who had advanced bronchial NEN and who underwent both [18F]FDG and [68Ga]Ga-DOTATATE PET within 60 days of each other. The NETPET score was assigned by experienced nuclear medicine physicians and compared with other clinical data such as WHO grade. The primary outcome was overall survival (OS); NETPET score and other prognostic variables were analysed using univariate and multivariate analyses by the Cox proportional-hazards model. Results: Thirty-eight patients were included for review. The NETPET score and histology were significantly correlated with OS in univariate analyses (P = 0.003, P = 0.01). On multivariate analysis, only the NETPET score remained significant (P = 0.03). The NETPET score was significantly associated with histological grade (P = 0.006, chi-squared test). Conclusion: The NETPET score is a prognostic biomarker in bronchial NENs as well as GEPNENs. Whilst it needs to be validated in prospective studies, it holds significant promise as a biomarker for a wide range of NENs.