RT Journal Article
SR Electronic
T1 PET/CT guided biopsy of suspected lung lesions requires less rebiopsy than CT guided biopsy due to inconclusive results
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP jnumed.120.252403
DO 10.2967/jnumed.120.252403
A1 Cerci, Juliano J.
A1 Bogoni, Mateos
A1 Cerci, Rodrigo J.
A1 Masukawa, Margaret
A1 Neto, Carlos C. P.
A1 Krauzer, Cassiano
A1 Fanti, Stefano
A1 Sakamoto, Danielle G.
A1 Barreiros, Renan B.
A1 Nanni, Cristina
A1 Vitola, João V.
YR 2020
UL http://jnm.snmjournals.org/content/early/2020/12/31/jnumed.120.252403.abstract
AB The purpose of this study is to compare FDG PET/CT and CT performance in guiding percutaneous biopsies with histological confirmation of lung lesions. Methods: We prospectively evaluated 341 patients of whom 216 underwent FDG PET/CT-guided biopsy and 125 underwent CT-guided biopsy. The pathology results, lesion size, complications and rebiopsy rate in the two groups were evaluated. Results: Of the 216 biopsies with PET/CT guidance, histology demonstrated 170 lesions (78.7%) to be malignant, and 46 (21.3%) to be benign; In the CT guided group, out of 125 lesions, 77 (61.6%) were malignant and 48 (38.4%) were benign (p = 0.001). Inconclusive results prompted the need for a second biopsy in 18 patients, 13/125 (10.4%) in the CT group and 5 /216 (2.3%) in PET group (p 0.001). Complications rates were: pneumothorax (13.2%), hemothorax (0.8%) and hemoptysis (0.6%). No life-threatening adverse events or fatalities were reported. The difference between complication rates among the 2 groups was not significant (P = 0.6). Malignant lesions showed greater mean size than benign lesions regardless of the group (P = 0.015). Conclusion: PET/CT guided biopsy of lung lesions led to fewer inconclusive biopsies in comparison with CT guided biopsy, with similar complication rates.