RT Journal Article
SR Electronic
T1 What is T+? A Gordian Knot of Tracers, Thresholds & Topographies
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP jnumed.120.245423
DO 10.2967/jnumed.120.245423
A1 Victor L. Villemagne
A1 Brian J. Lopresti
A1 Vincent Dore
A1 Dana Tudorascu
A1 Milos D. Ikonomovic
A1 Samantha Burnham
A1 Davneet Minhas
A1 Tharick A. Pascoal
A1 N. Scott Mason
A1 Beth Snitz
A1 Howard Aizenstein
A1 Chester A. Mathis
A1 Oscar Lopez
A1 Christopher C. Rowe
A1 William E. Klunk
A1 Ann D. Cohen
YR 2020
UL http://jnm.snmjournals.org/content/early/2020/12/31/jnumed.120.245423.abstract
AB In this review we examine, in the context of the AT(N) framework, the available evidence as well as the potential alternatives on how to establish tau-positivity (T+) for multiple tau imaging tracers in order to come to a consensus for “normal” and “abnormal” tau imaging values that can be universally implemented in clinical research and therapeutic trials.