PT  - JOURNAL ARTICLE
AU  - Victor L. Villemagne
AU  - Brian J. Lopresti
AU  - Vincent Dore
AU  - Dana Tudorascu
AU  - Milos D. Ikonomovic
AU  - Samantha Burnham
AU  - Davneet Minhas
AU  - Tharick A. Pascoal
AU  - N. Scott Mason
AU  - Beth Snitz
AU  - Howard Aizenstein
AU  - Chester A. Mathis
AU  - Oscar Lopez
AU  - Christopher C. Rowe
AU  - William E. Klunk
AU  - Ann D. Cohen
TI  - What is T+? A Gordian Knot of Tracers, Thresholds & Topographies
AID  - 10.2967/jnumed.120.245423
DP  - 2020 Dec 01
TA  - Journal of Nuclear Medicine
PG  - jnumed.120.245423
4099  - http://jnm.snmjournals.org/content/early/2020/12/31/jnumed.120.245423.short
4100  - http://jnm.snmjournals.org/content/early/2020/12/31/jnumed.120.245423.full
AB  - In this review we examine, in the context of the AT(N) framework, the available evidence as well as the potential alternatives on how to establish tau-positivity (T+) for multiple tau imaging tracers in order to come to a consensus for “normal” and “abnormal” tau imaging values that can be universally implemented in clinical research and therapeutic trials.