@article {Klugejnumed.120.247924, author = {Regine Kluge and Tim Wittig and Thomas Walter Georgi and Lars Kurch and Osama Sabri and W. Hamish Wallace and Tomasz Klekawka and Ana Fern{\'a}ndez-Teijeiro and Francesco Ceppi and Jonas Karl{\'e}n and Jane Pears and Michaela Cepelov{\'a} and Alexander Foss{\r a} and Auke Beishuizen and Lisa Lyngsie Hjalgrim and Dieter K{\"o}rholz and Christine Mauz-K{\"o}rholz and Dirk Hasenclever}, title = {Comparison of interim PET response to second-line vs. to first-line treatment in classical Hodgkin lymphoma {\textendash} contribution to the development of response criteria for relapsed or progressive disease}, elocation-id = {jnumed.120.247924}, year = {2020}, doi = {10.2967/jnumed.120.247924}, publisher = {Society of Nuclear Medicine}, abstract = {Rationale: In first-line treatment of Hodgkin lymphoma (HL) Deauville scores 1-3 define complete metabolic remission. Interim FDG-PET is also used for relapse treatment adaptation, however PET-response criteria are not validated for relapse treatment. Methods: We performed a pairwise comparative analysis of early treatment response to first-line and to second-line treatment in 127 patients with classical Hodgkin lymphoma who experienced relapse. Patients participated in the prospective, multicenter EuroNet-PHL-C1 study. Residual uptake was measured retrospectively using the qPET method, a validated semiautomatic quantitative extension of the Deauville score. Empirical cumulative distribution functions (ECDF) of the qPET values were used to systematically analyze the response to first-line and second-line treatment. Results and Conclusion: Individual patients responded variably to first-line and second line treatment. However, the ECDF of the qPET values from all patients were nearly superimposable. This supports that first-line and second-line treatment in HL do not require different response criteria.}, issn = {0161-5505}, URL = {https://jnm.snmjournals.org/content/early/2020/12/18/jnumed.120.247924}, eprint = {https://jnm.snmjournals.org/content/early/2020/12/18/jnumed.120.247924.full.pdf}, journal = {Journal of Nuclear Medicine} }