RT Journal Article
SR Electronic
T1 Cardiac Beta-Adrenergic Receptor Downregulation, Evaluated by Cardiac Positron Emission Tomography, in Chronotropic Incompetence
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP jnumed.120.253419
DO 10.2967/jnumed.120.253419
A1 Goto, Toshihiko
A1 Kikuchi, Shohei
A1 Mori, Kento
A1 Nakayama, Takafumi
A1 Fukuta, Hidekatsu
A1 Seo, Yoshihiro
A1 Narita, Hitomi
A1 Iida, Akihiko
A1 Ohte, Nobuyuki
YR 2020
UL http://jnm.snmjournals.org/content/early/2020/12/18/jnumed.120.253419.abstract
AB The mechanism of chronotropic incompetence (CI), which has been associated with autonomic dysfunction, has not been elucidated in patients without heart failure (HF). Methods: Cardiac positron emission tomography using 11C-CGP12177 was performed to investigate the cardiac beta-adrenergic receptor density (β-ARD) in 13 patients with CI without HF and six healthy controls. The maximum number of available specific 11C-CGP12177 binding sites per gram of tissue was calculated in regions of interest using an established graphical method. Results: Peak heart rate was significantly lower in CI patients than in controls (116.9 ± 11.0 vs. 154.8 ± 14.4 beats/min, p < 0.001). β-ARD of the total myocardium was significantly lower in CI patients than in controls (4.3 ± 1.7 vs. 7.0 ± 1.7 pmol/mL, p = 0.005). Conclusion: Beta-adrenergic receptor downregulation was demonstrated in patients with CI without HF. Decreased β-ARD is a common feature in patients with CI, with or without HF.