RT Journal Article SR Electronic T1 Machine Learning in Nuclear Medicine: Part 2—Neural Networks and Clinical Aspects JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 22 OP 29 DO 10.2967/jnumed.119.231837 VO 62 IS 1 A1 Zukotynski, Katherine A1 Gaudet, Vincent A1 Uribe, Carlos F. A1 Mathotaarachchi, Sulantha A1 Smith, Kenneth C. A1 Rosa-Neto, Pedro A1 Bénard, François A1 Black, Sandra E. YR 2021 UL http://jnm.snmjournals.org/content/62/1/22.abstract AB This article is the second part in our machine learning series. Part 1 provided a general overview of machine learning in nuclear medicine. Part 2 focuses on neural networks. We start with an example illustrating how neural networks work and a discussion of potential applications. Recognizing that there is a spectrum of applications, we focus on recent publications in the areas of image reconstruction, low-dose PET, disease detection, and models used for diagnosis and outcome prediction. Finally, since the way machine learning algorithms are reported in the literature is extremely variable, we conclude with a call to arms regarding the need for standardized reporting of design and outcome metrics and we propose a basic checklist our community might follow going forward.