RT Journal Article
SR Electronic
T1 Imaging the Distribution of Gastrin-Releasing Peptide Receptors in Cancer
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 792
OP 798
DO 10.2967/jnumed.119.234971
VO 61
IS 6
A1 Baratto, Lucia
A1 Duan, Heying
A1 Mäcke, Helmut
A1 Iagaru, Andrei
YR 2020
UL http://jnm.snmjournals.org/content/61/6/792.abstract
AB Targeting tumor-expressed receptors using selective molecules for diagnostic, therapeutic, or both diagnostic and therapeutic (theragnostic) purposes is a promising approach in oncologic applications. Such approaches have increased significantly over the past decade. Peptides such as gastrin-releasing peptide receptors targeting radiopharmaceuticals are small molecules with fast blood clearance and urinary excretion. They demonstrate good tissue diffusion, low immunogenicity, and highly selective binding to their target cell-surface receptors. They are also easily produced. Gastrin-releasing peptide receptors, part of the bombesin family, are overexpressed in many tumors, including breast and prostate cancer, and therefore represent an attractive target for future development.