PT  - JOURNAL ARTICLE
AU  - Lucia Baratto
AU  - Heying Duan
AU  - Helmut Mäcke
AU  - Andrei Iagaru
TI  - Imaging the Distribution of Gastrin-Releasing Peptide Receptors in Cancer
AID  - 10.2967/jnumed.119.234971
DP  - 2020 Jun 01
TA  - Journal of Nuclear Medicine
PG  - 792--798
VI  - 61
IP  - 6
4099  - http://jnm.snmjournals.org/content/61/6/792.short
4100  - http://jnm.snmjournals.org/content/61/6/792.full
SO  - J Nucl Med2020 Jun 01; 61
AB  - Targeting tumor-expressed receptors using selective molecules for diagnostic, therapeutic, or both diagnostic and therapeutic (theragnostic) purposes is a promising approach in oncologic applications. Such approaches have increased significantly over the past decade. Peptides such as gastrin-releasing peptide receptors targeting radiopharmaceuticals are small molecules with fast blood clearance and urinary excretion. They demonstrate good tissue diffusion, low immunogenicity, and highly selective binding to their target cell-surface receptors. They are also easily produced. Gastrin-releasing peptide receptors, part of the bombesin family, are overexpressed in many tumors, including breast and prostate cancer, and therefore represent an attractive target for future development.