TY - JOUR T1 - Efficacy of Peptide Receptor Radionuclide Therapy for Esthesioneuroblastoma JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 1326 LP - 1330 DO - 10.2967/jnumed.119.237990 VL - 61 IS - 9 AU - Olfat Kamel Hasan AU - Aravind S. Ravi Kumar AU - Grace Kong AU - Kira Oleinikov AU - Simona Ben-Haim AU - Simona Grozinsky-Glasberg AU - Rodney J. Hicks Y1 - 2020/09/01 UR - http://jnm.snmjournals.org/content/61/9/1326.abstract N2 - Esthesioneuroblastoma is rare, with limited therapeutic options when unresectable or metastatic; however, expression of somatostatin receptors qualifies it for peptide receptor radionuclide therapy (PRRT). We report outcomes of PRRT in esthesioneuroblastoma from 2 referral centers. Methods: Using PRRT databases at 2 European Neuroendocrine Tumor Society Centers of Excellence, cases were sought between 2004 and 2018 of patients who had PRRT with recurrent or metastatic esthesioneuroblastoma deemed unsuitable for further conventional therapies. Evaluations of survival and of response using a composite reference standard were performed. Results: Of 7 patients, 4 had partial response, 2 had disease stabilization, and one had early progression. Possible side effects include worsening cerebrospinal fluid leaks. Median progression-free survival was 17 mo (range, 0–30 mo), and median overall survival was 32 mo (range, 4–53 mo). Conclusion: PRRT shows promising efficacy and moderate survival duration in unresectable locally advanced or metastatic esthesioneuroblastoma warranting larger cohort studies incorporating measures of quality of life. ER -