RT Journal Article
SR Electronic
T1 α<sub>v</sub>β<sub>6</sub>-Targeted Molecular PET/CT Imaging of the Lungs After SARS-CoV-2 Infection
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1717
OP 1719
DO 10.2967/jnumed.120.255364
VO 61
IS 12
A1 Foster, Cameron C.
A1 Davis, Ryan A.
A1 Hausner, Sven H.
A1 Sutcliffe, Julie L.
YR 2020
UL http://jnm.snmjournals.org/content/61/12/1717.abstract
AB The true impact and long-term damage to organs such as the lungs after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remain to be determined. Noninvasive molecularly targeted imaging may play a critical role in aiding visualization and understanding of the systemic damage. We have identified αvβ6 as a molecular target; an epithelium-specific cell surface receptor that is low or undetectable in healthy adult epithelium but upregulated in select injured tissues, including fibrotic lung. Herein we report the first human PET/CT images using the integrin αvβ6-binding peptide (18F-αvβ6-BP) in a patient 2 mo after the acute phase of infection. Minimal uptake of 18F-αvβ6-BP was noted in normal lung parenchyma, with uptake being elevated in areas corresponding to opacities on CT. This case suggests that 18F-αvβ6-BP PET/CT is a promising noninvasive approach to identify the presence and potentially monitor the persistence and progression of lung damage.