RT Journal Article
SR Electronic
T1 CXCR4-targeted positron emission tomography imaging of central nervous system B-cell lymphoma
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP jnumed.120.241703
DO 10.2967/jnumed.120.241703
A1 Herhaus, Peter
A1 Lipkova, Jana
A1 Lammer, Felicitas
A1 Yakushev, Igor
A1 Vag, Tibor
A1 Slotta-Huspenina, Julia
A1 Habringer, Stefan
A1 Lapa, Constantin
A1 Pukrop, Tobias
A1 Hellwig, Dirk
A1 Wiestler, Benedikt
A1 Buck, Andreas K.
A1 Deckert, Martina
A1 Wester, Hans-Juergen
A1 Bassermann, Florian
A1 Schwaiger, Markus
A1 Weber, Wolfgang Andreas
A1 Menze, Bjoern
A1 Keller, Ulrich
YR 2020
UL http://jnm.snmjournals.org/content/early/2020/04/23/jnumed.120.241703.abstract
AB C-X-C chemokine receptor 4 is a transmembrane chemokine receptor involved in growth, survival, and dissemination of cancer, including aggressive B-cell lymphoma. Magnetic resonance imaging (MRI) is the standard imaging technology for central nervous system involvement of B-cell lymphoma and provides high sensitivity but moderate specificity. Therefore, novel molecular and functional imaging strategies are urgently required. Methods: In this proof-of-concept study, 11 patients with lymphoma of the CNS (CNSL, n = 8 primary and n = 3 secondary involvement) were imaged with the CXCR4-directed positron emission tomography (PET) tracer 68Ga-Pentixafor. To evaluate the predictive value of this imaging modality, treatment response, as determined by MRI, was correlated with quantification of CXCR4 expression by 68Ga-Pentixafor PET in vivo before initiation of treatment in 7 of 11 patients. Results: 68Ga-Pentixafor-PET showed excellent contrast characteristics to the surrounding brain parenchyma in all patients with active disease. Furthermore, initial CXCR4 uptake determined by PET correlated with subsequent treatment response as assessed by MRI. Conclusion: 68Ga-Pentixafor-PET represents a novel diagnostic tool for central nervous system lymphoma with potential implications for theranostic approaches as well as response and risk assessment.