RT Journal Article
SR Electronic
T1 Imaging the Distribution of Gastrin Releasing Peptide Receptors in Cancer
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP jnumed.119.234971
DO 10.2967/jnumed.119.234971
A1 Baratto, Lucia
A1 Duan, Heying
A1 Maecke, Helmut R.
A1 Iagaru, Andrei
YR 2020
UL http://jnm.snmjournals.org/content/early/2020/02/13/jnumed.119.234971.abstract
AB Targeting tumor-expressed receptors using selective molecules for diagnostic, therapeutic or both diagnostic and therapeutic (theragnostic) purposes is a promising approach in oncological applications. Such approaches have increased significantly over the past decade. Peptides such as gastrin-releasing peptide receptors (GRPR) targeting radiopharmaceuticals are small molecules with fast blood clearance and urinary excretion. They demonstrate good tissue diffusion, low immunogenicity, and highly selective binding to their target cell-surface receptors. They are also easily produced. GRPR, part of the bombesin (BBN) family, are overexpressed in many tumors, including breast and prostate cancer, and therefore represent an attractive target for future development.