RT Journal Article
SR Electronic
T1 Trending: Radioactive and fluorescent bimodal/hybrid tracers as multiplexing solutions for surgical guidance
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP jnumed.119.228684
DO 10.2967/jnumed.119.228684
A1 van Leeuwen, Fijs W.B.
A1 Schottelius, Margret
A1 Brouwer, Oscar Roberto
A1 Vidal-Sicart, Sergi
A1 Achilefu, Samuel
A1 Klode, Joachim
A1 Wester, Hans-Jurgen
A1 Buckle, Tessa
YR 2019
UL http://jnm.snmjournals.org/content/early/2019/11/07/jnumed.119.228684.abstract
AB By contributing to non-invasive molecular imaging and radioguided surgery, nuclear medicine has been instrumental in the realization of precision medicine. During the last decade it has also became apparent that nuclear medicine (e.g., in the form of bimodal/hybrid tracers) can help empower fluorescence guided surgery. More specifically, when using hybrid tracers, lesions can be non-invasively identified and localized with a high sensitively and precision (guided by the radioisotope) and ultimately resected under real-time optical guidance (fluorescent dye). This topical review discusses early clinical successes, preclinical directions and key aspects that could impact the future of this field.