TY - JOUR T1 - Standardized Expression of <sup>18</sup>F-NAV4694 and <sup>11</sup>C-PiB beta-Amyloid PET Results with the Centiloid Scale JF - Journal of Nuclear Medicine JO - J Nucl Med DO - 10.2967/jnumed.115.171595 SP - jnumed.115.171595 AU - Christopher C Rowe AU - Gareth Jones AU - Vincent Dore AU - Svetlana Pejoska AU - Laura Margison AU - Rachel S Mulligan AU - J Gordon Chan AU - Kenneth Young AU - Victor L Villemagne Y1 - 2016/02/01 UR - http://jnm.snmjournals.org/content/early/2016/02/16/jnumed.115.171595.abstract N2 - A common quantitative output value for β-amyloid (Aβ imaging across tracers and methods will allow better comparison of data across sites and application of universal diagnostic and prognostic values. A method has recently been developed that generates a unit of measurement called the Centiloid (Klunk et al, Alzheimers Dement, 2015). We applied this method on 18F-NAV4694 (NAV4694) and 11C-PiB (PiB) Aβ images to derive the scaling factor required to express tracer binding in Centiloids (CL). Methods: Fifty-five participants, including 10 healthy young controls (33±7 yo), underwent both PiB and NAV4694 imaging with less than 3 months between scans. Images were acquired from 50 to 70 min post injection. Spatially normalized images were analyzed using the standard Centiloid method and regions (cortex and whole cerebellum reference) downloaded from the Global Alzheimer's Association Interactive Network website (http://www.gaain.org). Results: Tracer binding was highly correlated (SUVRNAV4694 = 1.09 x SUVRPiB – 0.08, R2 = 0.99). The equation to convert NAV4694 (CL = 100 x (SUVRNAV4694 – 1.028)/1.174) was similar to the published equation for PiB (CL = 100 x (SUVRPIB – 1.009)/1.067). NAV4694 variance in the young controls compared to PiB was 0.85 (SDNAV4694/SDPiB). Conclusion: Both PiB and NAV4694 results can now be expressed in Centiloids, an important step that should allow better clinical and research use of Aβ imaging. The standard Centiloid method also showed that NAV4694 has slightly higher Aβ binding and lower variance than PiB, important properties for detecting early Aβ deposition and change over time. ER -