RT Journal Article SR Electronic T1 Fast Spiral SPECT with Stationary γ-Cameras and Focusing Pinholes JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP jnumed.111.101899 DO 10.2967/jnumed.111.101899 A1 Pieter E.B. Vaissier A1 Marlies C. Goorden A1 Brendan Vastenhouw A1 Frans van der Have A1 Ruud M. Ramakers A1 Freek J. Beekman YR 2012 UL http://jnm.snmjournals.org/content/early/2012/06/15/jnumed.111.101899.1.abstract AB Small-animal SPECT systems with stationary detectors and focusing multiple pinholes can achieve excellent resolution–sensitivity trade-offs. These systems are able to perform fast total-body scans by shifting the animal bed through the collimator using an automated xyz stage. However, so far, a large number of highly overlapping central fields of view have been used, at the cost of overhead time needed for animal repositioning and long image reconstruction times due to high numbers of projection views. Methods: To improve temporal resolution and reduce image reconstruction time for such scans, we have developed and tested spiral trajectories (STs) of the animal bed requiring fewer steps. In addition, we tested multiplane trajectories (MPTs) of the animal bed, which is the standard acquisition method of the U-SPECT-II system that is used in this study. Neither MPTs nor STs require rotation of the animal. Computer simulations and physical phantom experiments were performed for a wide range of numbers of bed positions. Furthermore, we tested STs in vivo for fast dynamic mouse scans. Results: We found that STs require less than half the number of bed positions of MPTs to achieve sufficient sampling. The reduced number of bed positions made it possible to perform a dynamic total-body bone scan and a dynamic hepatobiliary scan with time resolutions of 60 s and 15 s, respectively. Conclusion: STs open up new possibilities for high throughput and fast dynamic radio-molecular imaging.