PT  - JOURNAL ARTICLE
AU  - Youngho Seo
AU  - Carina Mari Aparici
AU  - Chien Peter Chen
AU  - Charles Hsu
AU  - Norbert Kased
AU  - Carole Schreck
AU  - Nick Costouros
AU  - Randall Hawkins
AU  - Katsuto Shinohara
AU  - Mack Roach III
TI  - Mapping of Lymphatic Drainage from the Prostate Using Filtered <sup>99m</sup>Tc-Sulfur Nanocolloid and SPECT/CT
AID  - 10.2967/jnumed.110.085944
DP  - 2011 Jul 01
TA  - Journal of Nuclear Medicine
PG  - 1068--1072
VI  - 52
IP  - 7
4099  - http://jnm.snmjournals.org/content/52/7/1068.short
4100  - http://jnm.snmjournals.org/content/52/7/1068.full
SO  - J Nucl Med2011 Jul 01; 52
AB  - We have developed a practice procedure for prostate lymphoscintigraphy using SPECT/CT and filtered 99mTc-sulfur nanocolloid, as an alternative to the proprietary product 99mTc-Nanocoll, which is not approved in the United States. Methods: Ten patients were enrolled for this study, and all received radiotracer prepared using a 100-nm membrane filter at a commercial radiopharmacy. Whole-body scans and SPECT/CT studies were performed within 1.5–3 h after the radiotracer had been administered directly into 6 locations of the prostate gland under transrectal ultrasound guidance. The radiation dose was estimated from the first 3 patients. Lymphatic drainage mapping was performed, and lymph nodes were identified. Results: The estimated radiation dose ranged from 3.9 to 5.2 mSv/MBq. The locations of lymph nodes draining the prostate gland were similar to those found using the proprietary product. Conclusion: When the proprietary radiolabeled nanocolloid indicated for lymphoscintigraphy is not available, prostate lymph node mapping and identification are still feasible using filtered 99mTc-sulfur nanocolloid.