TY - JOUR T1 - Metastatic Renal Cell Carcinoma: Relationship Between Initial Metastasis Hypoxia, Change After 1 Month's Sunitinib, and Therapeutic Response: An <sup>18</sup>F-Fluoromisonidazole PET/CT Study JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 1048 LP - 1055 DO - 10.2967/jnumed.110.084517 VL - 52 IS - 7 AU - Florent Hugonnet AU - Laure Fournier AU - Jacques Medioni AU - Corinne Smadja AU - Elif Hindié AU - Virginie Huchet AU - Emmanuel Itti AU - Charles-André Cuenod AU - Gilles Chatellier AU - Stéphane Oudard AU - Marc Faraggi AU - for the Hypoxia in Renal Cancer (HYRC) Multicenter Group Y1 - 2011/07/01 UR - http://jnm.snmjournals.org/content/52/7/1048.abstract N2 - The aims of this cohort study were to evaluate initial tumor hypoxia in metastatic renal cell carcinoma (mRCC) and its changes after sunitinib treatment, using 18F-fluoromisonidazole PET/CT, and investigate the possible prognostic value of initial tumor hypoxia or its changes under sunitinib therapy. Methods: Antiangiogenic-naive patients with mRCC were prospectively enrolled in this cohort study. Before initiation of sunitinib, CT defined up to 10 targets that were assessed at 1 and 6 mo according to the response evaluation criteria in solid tumors (RECIST). Pretreatment target uptake of 18F-fluoromisonidazole was compared with uptake at 1 mo. Targets were considered hypoxic when their maximal standard uptake value was above mean blood value + 2 SDs. Hypoxic volumes were also computed. Relationships between initial hypoxia status, initial degree of hypoxia, its change at 1 mo, and overall or progression-free survival (OS and PFS, respectively) were assessed by survival analysis. Results: Fifty-three patients were included. Median follow-up was 16.8 mo. 18F-fluoromisonidazole uptake significantly decreased in initially hypoxic target metastases but did not change in others (−22%, P &lt; 10−4, vs. +1.5%, P = 0.77; P = 10−3 between groups). Seventy-five percent of patients with hypoxic metastases were free of progressive disease at 4.8 mo (95% confidence interval, 2.99–11.83), compared with 11.3 mo (95% confidence interval, 3.08–36.9) for other patients (P = 0.02), whereas OS was not significantly different. Changes in tumor hypoxia were not related to PFS or OS. Conclusion: Sunitinib reduced hypoxia in initially hypoxic RECIST target metastases but did not induce significant hypoxia in nonhypoxic RECIST target metastases. Patients with initially hypoxic targets have shorter PFS than others. ER -