PT  - JOURNAL ARTICLE
AU  - Min-Fu Tsan
TI  - Mechanism of Gallium-67 Accumulation in Inflammatory Lesions
DP  - 1985 Jan 01
TA  - Journal of Nuclear Medicine
PG  - 88--92
VI  - 26
IP  - 1
4099  - http://jnm.snmjournals.org/content/26/1/88.short
4100  - http://jnm.snmjournals.org/content/26/1/88.full
SO  - J Nucl Med1985 Jan 01; 26
AB  - Multiple factors contribute to the accumulation and retention of gallium-67 in inflammatory lesions. Adequate blood supply is essential. Gallium-67, mainly in the from of transferring-Ga-67 complex, is delivered to the inflammatory lesions through capillaries with increased permeability. At the site of inflammation, some Ga-67 is taken up by leukocytes and bacteria when they are present. In addition, Ga-67 may also bind to lactoferrin and bacterial siderophores. Multiple contributing factors often coexist at any given inflammatory lesion. The nature and intensity of the inflammation affects the relative contribution of these factors. Thus, there may be situations in which all the contributing factors are present, but in such a low intensity that they escape clinical detection by Ga-67 scans. On the other hand, there may be situations in which one or more contributing factors are missing, such as in patients with agranulocytosis, while they are readily detected by Ga-67 scans.