TY - JOUR T1 - Lung Tumor Imaging by Positron Emission Tomography Using C-11 <span class="sc">L</span>-Methionine JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 37 LP - 42 VL - 26 IS - 1 AU - Kazuo Kubota AU - Taiju Matsuzawa AU - Masatoshi Ito AU - Kengo Ito AU - Takehiko Fujiwara AU - Yoshinao Abe AU - Seiro Yoshioka AU - Hiroshi Fukuda AU - Jun Hatazawa AU - Ren Iwata AU - Seiichi Watanuki AU - Tatsuo Ido Y1 - 1985/01/01 UR - http://jnm.snmjournals.org/content/26/1/37.abstract N2 - This paper described the first clinical study of lung tumor scanning by positron emission tomography (PET) using C-11-labeled L-methionine (11C-L-Met). Tumor images were clearly visualized by high contrast in eight lung cancer patients and also in a patient with a silicotic nodule. Quantitative evaluations of methionine uptake in tumor tissue and normal tissue by comparing differential uptake ratios suggested that the extent to which 11C-L-Met accumulates in a tumor is closely correlated to the tumor's viability such as benign or malignant, viable or necrotic. 11C-L-Met is considered to be an effective tumor marker for PET diagnosis which represents increased amino acid metabolism of tumors in the mediastinum and lung. ER -