TY - JOUR T1 - A Sensitive Human Thyroglobulin RIA to Define Clearly the Presence or Absence of Functioning Thyroid Tissue JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 49 LP - 55 VL - 25 IS - 1 AU - Irene Lemish AU - Francis Bennett AU - Clayton Martin AU - Anthony Warwick AU - Michael Quinlan Y1 - 1984/01/01 UR - http://jnm.snmjournals.org/content/25/1/49.abstract N2 - This paper describes a practical procedure to establish a sensitive radioimmunoassay for the measurement of human thyroglobulin (HTg) in serum. The assay enables a clear distinction to be made between levels of HTg indicating the presence or absence of functioning thyroid tissue. It compares the use of HTg serum levels with the conventional I-131 scintigram as a marker for recurrent thyroid cancer. In addition, a simple and sensitive radioimmunologic assay is described for the determination of serum antithyroglobulin autoantibodies, the presence of which may give falsely elevated HTg levels. ER -