RT Journal Article SR Electronic T1 A Sensitive Human Thyroglobulin RIA to Define Clearly the Presence or Absence of Functioning Thyroid Tissue JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 49 OP 55 VO 25 IS 1 A1 Irene Lemish A1 Francis Bennett A1 Clayton Martin A1 Anthony Warwick A1 Michael Quinlan YR 1984 UL http://jnm.snmjournals.org/content/25/1/49.abstract AB This paper describes a practical procedure to establish a sensitive radioimmunoassay for the measurement of human thyroglobulin (HTg) in serum. The assay enables a clear distinction to be made between levels of HTg indicating the presence or absence of functioning thyroid tissue. It compares the use of HTg serum levels with the conventional I-131 scintigram as a marker for recurrent thyroid cancer. In addition, a simple and sensitive radioimmunologic assay is described for the determination of serum antithyroglobulin autoantibodies, the presence of which may give falsely elevated HTg levels.