%0 Journal Article %A Irene Lemish %A Francis Bennett %A Clayton Martin %A Anthony Warwick %A Michael Quinlan %T A Sensitive Human Thyroglobulin RIA to Define Clearly the Presence or Absence of Functioning Thyroid Tissue %D 1984 %J Journal of Nuclear Medicine %P 49-55 %V 25 %N 1 %X This paper describes a practical procedure to establish a sensitive radioimmunoassay for the measurement of human thyroglobulin (HTg) in serum. The assay enables a clear distinction to be made between levels of HTg indicating the presence or absence of functioning thyroid tissue. It compares the use of HTg serum levels with the conventional I-131 scintigram as a marker for recurrent thyroid cancer. In addition, a simple and sensitive radioimmunologic assay is described for the determination of serum antithyroglobulin autoantibodies, the presence of which may give falsely elevated HTg levels. %U https://jnm.snmjournals.org/content/jnumed/25/1/49.full.pdf