RT Journal Article
SR Electronic
T1 A Comparison of Two Cerebral Perfusion Tracers, N-Isopropyl I-123 p-Iodoamphetamine and I-123 HIPDM, in the Human
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 25
OP 30
VO 25
IS 1
A1 B. Leonard Holman
A1 Robert G. L. Lee
A1 Thomas C. Hill
A1 Richard D. Lovett
A1 John Lister-James
YR 1984
UL http://jnm.snmjournals.org/content/25/1/25.abstract
AB Both N-isopropyl I-123 p-iodoamphetamine (IMP) and I-123 HIPDM have been advocated as radiotracers for assessing regional cerebral perfusion. We compared the biodistribution of the two tracers in 19 patients without evidence of neurological disease. Following intravenous injection, both tracers accumulated initially in the lung. Early after injection the fraction of the total brain uptake was higher for I-123 HIPDM than for I-123 IMP. The peak brain activity for I-123 IMP was higher than for I-123 HIPDM. Brain activity was unchanged with both tracers between 30 and 60 min after injection. Tomographic images were similar in appearance for both tracers. No eye uptake greater than background was observed with either tracer in any patient at 2, 24, and 48 hr. I-123 IMP is superior for tomographic imaging because of its higher brain uptake, whereas I-123 HIPDM may be superior for studies performed during rapid changes in blood flow.