PT  - JOURNAL ARTICLE
AU  - Wu, Chen
AU  - Cheng, Yan
AU  - Luo, Liping
AU  - Tong, Huimin
AU  - Guo, Xiaoshan
AU  - Wu, Zhifang
TI  - The diagnostic value of peak filling rate derived from gated myocardial SPECT in myocardial ischemia of non-obstructive coronary artery disease
DP  - 2020 May 01
TA  - Journal of Nuclear Medicine
PG  - 1594--1594
VI  - 61
IP  - supplement 1
4099  - http://jnm.snmjournals.org/content/61/supplement_1/1594.short
4100  - http://jnm.snmjournals.org/content/61/supplement_1/1594.full
SO  - J Nucl Med2020 May 01; 61
AB  - 1594Objectives: To investigate the diagnostic value of gated myocardial tomography (SPECT) imaging peak filling rate (PFR) for myocardial ischemia in non-obstructive coronary artery disease(CAD). Methods: Retrospective analysis of 86 patients with coronary artery stenosis less than 50% from January 2015 to June 2019. All patients were performed rest and stress gated 99Tcm-MIBI SPECT perfusion imaging. According to the stress-test myocardial perfusion imaging summed differenct scores(SDS),they were divided into myocardial ischemia group (49 cases) and normal myocardial imaging group (37 cases). Myocardial perfusion images were analyzed with quantitative perfusion SPECT(QPS) software to obtain total resting perfusion scores (SRS). The stress-rest cardiac function parameters, including left ventricular ejection fraction (LVEF), the end-diastolic volume(EDV), end-systolic volume(ESV) and peak filling rate(PFR), were calculated by QGS software. These parameters between two groups were compared. Results: The ischemic group of patients with non-obstructive CAD was compared with the non-ischemic group, the PFR (2.13 ± 0.27EDV / s, 1.89 ± 0.27EDV / s) of the myocardial ischemia group was significantly lower than that of the non-myocardial ischemia group (2.48 ± 0.31EDV / s, 2.30 ± 0.20EDV / s), with statistical differences ( P <0.05), and there was no obvious difference between left ventricular volume and LVEF(P> 0.05) (Table 1). Gender, age, body mass index, presence of hypertension and diabetes, EF and PFR in resting state, EF and PFR after stress test were included for binary logistic regression analysis, The results suggest that rest and after stress test PFR was a predictor of myocardial ischemia in patients with non-obstructive CAD (P < 0.05) (table 2). For the identification of myocardial ischemia in patients with non-obstructive CAD, ROC curve analysis showed: The optimal cut-off value of resting PFR was 2.005, AUC was 0.881 (95%CI: 0.806-0.955), specificity was 75.5%, and sensitivity was 97.3%; After the stress test, the optimal cut-off point value of PFR was 2.205, AUC was 0.811 (95%CI: 0.716-0.906), specificity was 65.3%, and sensitivity was 89.2% (figure 1). Conclusions: Gated myocardial SPECT with left ventricular diastolic function parameter PFR is helpful in the diagnosis of myocardial ischemia in patients with non-obstructive CAD.