PT  - JOURNAL ARTICLE
AU  - Tsujikawa, Tetsuya
AU  - Kanno, Masafumi
AU  - Narita, Norihiko
AU  - Fujieda, Shigeharu
AU  - Okazawa, Hidehiko
TI  - Zero TE-based PET/MR attenuation correction in patients with oral cavity cancer
DP  - 2020 May 01
TA  - Journal of Nuclear Medicine
PG  - 1299--1299
VI  - 61
IP  - supplement 1
4099  - http://jnm.snmjournals.org/content/61/supplement_1/1299.short
4100  - http://jnm.snmjournals.org/content/61/supplement_1/1299.full
SO  - J Nucl Med2020 May 01; 61
AB  - 1299Objectives: To demonstrate the feasibility of zero-echo-time (ZTE) MR imaging for jaw bones and to evaluate the quantitative performance of 2-[18F]-fluoro-2-deoxy-D-glucose (18F-FDG) PET/MRI with ZTE-based attenuation correction (ZTE-AC) compared with PET/CT and PET/MRI with Dixon-MR-based AC (MR-AC) in patients with oral cavity cancer (OCC). Methods: Thirteen patients with OCC underwent a whole-body 18F-FDG PET/CT scan and a subsequent regional PET/MR scan with MR-AC and ZTE-AC in one day. The standardized uptake values (SUVs) were measured on PET/CT (SUVCT-AC), PET/MRI with MR-AC (SUVMR-AC), and with ZTE-AC (SUVZTE-AC). The SUVs were correlated and compared with each other. Results: ZTE MR images minimized the effects of metal artifacts from dentures and ZTE-AC maps correctly delineated the jaw bones. SUVMR-AC and SUVZTE-AC showed significant positive correlations with SUVCT-AC (Pearson’s r = 0.95 and r = 0.98, respectively). The means ± SD of SUVCT-AC, SUVMR-AC and SUVZTE-AC were 12.8 ± 6.7, 12.8 ± 6.6, and 13.9 ± 7.1, respectively. SUVZTE-AC was significantly higher than SUVCT-AC (p < 0.05) whereas there was no significant difference between SUVCT-AC and SUVMR-AC or between SUVMR-AC and SUVZTE-AC. Conclusions: The ZTE MR images clearly delineate the jaw bones while minimizing the effects of metal artifacts. The ZTE-AC method in 18F-FDG PET/MRI reduces the underestimation of tracer uptake by MR-AC errors of jaw bones and improves the quantitative performance in patients with OCC.