TY - JOUR T1 - Augmented Whole-body Scanning via Magnifying PET JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 309 LP - 309 VL - 61 IS - supplement 1 AU - Jianyong Jiang AU - Suranjana Samanta AU - Ke Li AU - Mahdjoub Hamdi AU - Stefan B. Siegel AU - Robert Mintzer AU - Sanghee Cho AU - Maurizio Conti AU - Matthias Schmand AU - Richard Laforest AU - Joseph O’Sullivan AU - Yuan-chuan Tai Y1 - 2020/05/01 UR - http://jnm.snmjournals.org/content/61/supplement_1/309.abstract N2 - 309Introduction: A novel technique called augmented whole-body scanning via magnifying PET (AWSM-PET) that improves the sensitivity and lesion detectability of a clinical PET scanner for whole-body imaging is being developed. Methods: — A Siemens Biograph Vision PET/CT scanner equipped with one or two high-resolution panel-detectors was simulated to study the effectiveness of AWSM-PET technology. The detector panels are located immediately outside the scanner’s axial field-of-view (FOV). A detector-panel contains 4×8 detector modules each of which consists of 32×32 LSO crystals (1.0×1.0×10.0 mm3 each). A 22Na point source was stepped across the scanner’s FOV axially to measure sensitivity profiles at different locations. An elliptical torso phantom containing 7×9 spherical lesions was imaged at different axial locations to mimic a multi-bed-position whole-body imaging protocol. Receiver operating characteristic (ROC) curves were analyzed to evaluate the improvement in lesion detectability by the AWSM-PET technology. A prototype AWSM-PET system is currently under development. The initial design of a detector module consists of 32×32 LSO crystals (1.0×1.0×10.0 mm3 each) read out by a 4x4 SiPM array using standard electronics in a Siemens Biograph Vision scanner. Results: — Monte Carlo simulation shows 36%-42% improvement in system sensitivity by a dual-panel AWSM-PET device. The area under the ROC curve is 0.962 by a native scanner for the detection of 4 mm diameter lesions with 5:1 tumor-to-background activity concentration. It was improved to 0.977 and 0.991 with a single- and dual-panel AWSM-PET system, respectively. Initial tests of the prototype detector show an average coincidence resolving time of 178 ps (FWHM) and an average energy resolution of 11.4% FWHM at 511 keV. Conclusions: — The principle of the AWSM-PET technology has been validated. Simulation studies show an enhancement of overall system sensitivity of 37%-42% for a dual-panel AWSM-PET system. This technology also improves the lesion detectability of a whole-body PET scanner. Development of a prototype AWSM-PET device for the Siemens Biograph Vision PET/CT scanner is underway. Initial results from a prototype high-resolution detector show excellent timing resolution to support the TOF-PET operation of the native scanner and the integrated AWSM-PET device. This technology may offer a cost-effective path to realize high-resolution whole-body PET imaging clinically in the future. Acknowledgement: —This work was supported in part by the National Institute of Health (R01-CA233912) and the Mallinckrodt Institute of Radiology internal allotments. ER -