PT  - JOURNAL ARTICLE
AU  - Nishii, Ryuichi
AU  - Yamazaki, Kana
AU  - Kasuya, Goro
AU  - Makishima, Hirokazu
AU  - Chang, Tachen
AU  - Tamura, Kentaro
AU  - Tsuji, Hiroshi
AU  - Higashi, Tatsuya
TI  - Usefulness of <sup>99m</sup>Tc MAG<sub>3</sub> renogram for monitoring before and after carbon ion radiotherapy in patients with renal cell carcinoma
DP  - 2020 May 01
TA  - Journal of Nuclear Medicine
PG  - 1161--1161
VI  - 61
IP  - supplement 1
4099  - http://jnm.snmjournals.org/content/61/supplement_1/1161.short
4100  - http://jnm.snmjournals.org/content/61/supplement_1/1161.full
SO  - J Nucl Med2020 May 01; 61
AB  - 1161Introduction: Carbon‐ion radiotherapy (CIRT) for primary renal cell carcinoma (RCC) showed high local control rates (100% at 5 years) even in the inoperable patients. For clinical management after CIRT in RCC patients, evaluation of preserved renal function especially in non-irradiated renal parenchyma is important to assess and monitor the adverse event of renal function. Monitoring using eGFR is convenient and useful after CIRT in RCC, however, it is hard to evaluate the split function of the kidneys. It has been suggested that serial assessment of renal function by measuring tubular extraction with 99mTc-MAG3 might permit earlier and more sensitive detection of renal damage. <Patients> A total of 6 patients who had received CIRT for RCC; 3 patients for 66.0Gy/12Fractions and 3 patients for 72.0Gy/12Fractions were enrolled in this study. 99mTc-MAG3 renogram before, 3-6 months and 12-18 months after CIRT were analyzed. The effective renal plasma flow of both kidneys (total cERPF), peak time (min), T1/2 from the PT (min), C20/max index were calculated and were compared with their eGFR and the adverse events evaluation category of National Cancer Institute’s Common Terminology Criteria for Adverse Events (CTCAE) version 4.0 <Result and Summary> In the analysis using 99mTc-MAG3 renogram, it was possible to detect the renal function deterioration of non-irradiated renal parenchyma. In some patients, the 99mTc-MAG3 renogram showed renal function deterioration, which it might be not due to CIRT but systemic diseases or kidney diseases. 99mTc-MAG3 renogram is considered to be a useful diagnostic tool for the assessment of split renal function in CIRT for RCC. <Teaching Points> 1) 99mTc-MAG3 renogram is a useful non-invasive diagnostic tool to evaluate renal function after CIRT in patients with renal cell carcinoma, especially for the assessment of split renal function.2) With the 99mTc-MAG3 renogram, it is possible to detect renal function deterioration of non-irradiated renal parenchyma.3) Serial assessment of renal function by measuring tubular extraction with 99mTc-MAG3 might permit earlier and more sensitive detection of renal damage after CIRT.